MODULATORS OF THE TRANSCRIPTION FACTORS NF-KAPA B AND NRF2 AS A MEANS RESTRICTING THE DESTRUCTION OF THE PERIODONTAL EXTRACELLULAR MATRIX IN RATS AFTER EXPERIMENTAL CRANIOCEREBRAL INJURY

This paper describes the effect of NF-κB and Nrf2 transcription factor modulators on depolymerization periodontal extracellular matrix biopolymers in early post-traumatic period following modeling an experimental traumatic brain injury (TBI). The study was conducted 30 white Wistar male rats weighing 180-220 g, divided into 6 groups: 1st (pseudo-traumatized animals, control 1) scalp pinched with a Mikulicz clamp for one click (under ether anesthesia); 2nd included animals after TBI (control 2); other groups were intraperitoneally injected factors 7 days: ammonium pyrrolidine dithiocarbamate, inhibitor nuclear translocation NF-κB, dose 76 mg/kg, dimethyl fumarate, inducer Nrf2, 15 mg/kg 10% solution sulfoxide, bioflavonoids possessing properties, namely: epigallocatechin-3-gallate 1 water-soluble form quercetin (corvitin) 100 (10 terms quercetin). has shown that manifests increase collagenolysis proteoglycans sialoglycoproteins soft bone tissue at end (on 7th day) as evidenced by growth concentration free oxyproline, hexuronic acids N-acetylneuraminic acid homogenate these tissues. administration specific (ammonium dithiocarbamate respectively) herbal (epigallocatechin-3-gallate quercetin) significantly inhibits processes macromolecules connective structures (collagen, proteoglycans, glycoproteins) release their monomers (oxyproline, acids). article compares effectiveness use under conditions.